clonidine: an old friend newly rediscovered

Clonidine: An Old Friend Newly Rediscovered

Implication for health policy/practice/research/medical education: Clonidine, a relatively old anti-hypertensive agent, has been used during the last years, as an analgesic agent. Nowadays, this drug has been used not only orally, but also, intravenously and interathechally; which possibly suggest newer mechanisms. There are emerging evidence for this fact. Copyright © 2011, ISRAPM, Published b...

Buttonhole: an old technique rediscovered.

An old friend turns 100.

Severe Vivax Malaria: Newly Recognised or Rediscovered?

M alignant tertian " and " benign tertian " are terms that have long been used for two of the major diseases we recognise as malaria. The former is generally considered to be synonymous with Plasmodium falciparum and the latter with P. vivax infection. As the names " malignant " and " benign " suggest, the current dogma is that P. falciparum can be severe and life-threatening while P. vivax ten...

An old friend revisited: chloramphenicol optic neuropathy

A 66-year-old woman presented on October 2011 with a 10-day history of painless bilateral visual loss of subacute onset (over 48 h). She also described paraesthesiae of the limbs for a similar duration. She has rheumatoid arthritis, treated with methotrexate (since 2002) and etanercept (2003– 2009), and she required bilateral knee replacements in 2009. Her right knee replacement was revised and...

A new model for an old friend.

JGP study suggests the anion exchanger AE1 operates via an elevator-like mechanism.